As a healthcare backend support team, we’ve seen many midsize practices struggle to find an EHR or EMR system that truly fits their needs. More often than not, they end up choosing tools that are either too complex or too basic, leading to unnecessary frustration. Switching between systems not only disrupts the workflow but can also result in lost patient data, increased administrative workload, and financial setbacks.
As midsize healthcare practices continue to grow, many reach a tipping point where outdated tools or fragmented systems no longer support daily operations.
That’s where choosing the right EHR (Electronic Health Record) and Practice Management System (PMS) combo becomes critical.
In 2025, several platforms stand out for their ability to serve midsize practices with the balance of functionality, ease of use, and scalability. Here’s a look at the Top 10 Best EHR and Practice Management combo for Midsize Practices in the market and what FTBS thinks is ideal for practices in this category.
What Makes a Good EHR + PMS Combo?
For a midsize clinic, the best systems are those that go beyond just storing patient records. The ideal combo should:
- Handle scheduling, billing, charting, and reporting within one interface
- Improve patient experience through portals, reminders, and secure communication
- Offer strong claim submission and denial management features
- Be customizable to your specialty and workflows
- Scale easily as the practice grows
- Be cloud-based, compliant, and accessible across devices
Top EHR + Practice Management Combos for 2025
1. Athenahealth
Athenahealth remains a strong player due to its end-to-end features for both administrative and clinical tasks. It combines robust RCM tools, specialty-specific templates, and automation to simplify provider workflows. Athenahealth for growing practices is a great fit, thanks to its intuitive design and cloud-based access—especially for those managing multiple providers or service lines.
2. Kareo + Tebra
Following their merger, Kareo and Tebra offer a comprehensive platform suited for midsize independent practices. Their integrated system handles appointments, claims, charting, and patient communications smoothly. It’s particularly valued for its affordability, making it a great choice for practices transitioning from older systems without a large IT budget.
3. DrChrono
Known for its mobile-first design, DrChrono for practices supports flexible use on tablets and iPhones. It’s ideal for practices needing speed and convenience—especially those in fields like home health, primary care, or behavioral health. With e-prescribing, billing, and real-time insurance checks built in, it works well for teams looking to modernize without overcomplicating their workflows.
4. AdvancedMD
AdvancedMD for practices is supported with more complex structures or in-house billing teams. Its advanced scheduling, customizable charting, and detailed financial reporting make it one of the most feature-rich solutions on the market. While it requires a learning curve, it offers deep customization for specialties and multi-location clinics.
5. eClinicalWorks (eCW)
Best for: High-volume clinics focused on population health, compliance tracking, and documentation
eCW for practice management is known for its comprehensive clinical documentation and data-driven approach. It excels in managing large patient panels, with built-in tools for tracking CDSS (Clinical Decision Support Systems), HEDIS measures, and quality compliance.
Practices can easily manage faxes, integrate full patient intake forms, and maintain updated longitudinal records. If you need to maintain strong documentation for audits, value-based care programs, or public health reporting, eCW is a strategic choice.
6. Boulevard
Best for: hybrid wellness clinics
Boulevard for wellness, aesthetic, and boutique-style practices that combine healthcare with personal care services. Its modern interface supports appointment-based businesses with scheduling, integrated payments, and client relationship management.
It’s especially useful for clinics that offer memberships, packages, or custom services—like IV therapy, wellness coaching, or aesthetics—where patient experience and branding are key.
7. Elation Health
Best for: Primary care, relationship-based medicine, and DPC (Direct Primary Care) practices
Elation for Direct Primary care and functional medicine is known for its physician-first design, emphasizing simplicity, speed, and meaningful patient interactions. It allows clinicians to focus on care without excessive clicks, offering a problem-based charting interface, eRx, and lab integrations.
It’s an excellent choice for DPC and small primary care clinics where continuity of care, time savings, and documentation accuracy are top priorities.
8. NextGen Healthcare
Best for: Specialty practices, FQHCs, and large outpatient networks
NextGen offers deep specialty customizations, interoperability, and reporting features ideal for practices in cardiology, orthopedics, urology, and other complex fields. It also supports Federally Qualified Health Centers (FQHCs) and community health settings with sliding-scale billing and encounter-level documentation.
Its latest cloud version enhances access, while its strong analytics engine helps providers track outcomes, care gaps, and population health trends across large networks.
9. Epic (via Community Connect)
Best for: Hospital-affiliated outpatient clinics and enterprise networks
While traditionally reserved for large hospital systems, Epic’s Community Connect program allows smaller clinics to access Epic’s powerful ecosystem via partner networks. It enables seamless patient record sharing, referral management, and cross-provider communication.
Epic is ideal for clinics that are part of or closely collaborate with hospital systems and need integrated access to inpatient, outpatient, and lab data within a single unified platform.
10. Practice Fusion (by Veradigm)
Best for: Small practices seeking simplicity and low cost
Practice Fusion is a lightweight, web-based EHR designed for independent practices. It provides core features like e-prescribing, charting, labs, and scheduling with a clean, no-frills interface.
While not as robust as others, it’s widely used due to its ease of use, low cost, and suitability for providers who don’t need deep customizations. Now backed by Veradigm, it continues to improve with payer and lab integrations.
Things to Consider Before Choosing
Every practice operates differently, so the “best” EHR + PMS combo will depend on your:
- Specialty and clinical workflow
- Staff size and billing process
- Volume of patient visits and claims
- Need for reporting, analytics, and patient engagement tools
Before committing to a platform, schedule demos, involve both administrative and clinical staff, and explore how each system can adapt to your workflow—not the other way around.
Choosing the Best EHR and Practice Management combo for Midsize Practices can significantly reduce staff burnout, streamline patient flow, and boost revenue accuracy. The key is to find a system that fits your practice’s rhythm and growth plans—not just one with the most features.
If you’re unsure where to start, FTBS Healthcare Assistants works closely with clinics to help map operational needs and recommend the right tools based on specialty, team size, and long-term goals. Our team brings years of experience optimizing clinical and billing operations for practices across the country.